I would recommend setting only those large values โโof the page that they need, and not the site as a whole; both can be set programmatically for the page. Otherwise, I do not see a problem with increased latency and file size. You should probably include a warning that loading may take up to 5 minutes so that users do not click buttons (i.e. ajax progress bar).
System.Web.Configuration.HttpRuntimeSection.MaxRequestLength and Server.ScriptTimeout
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