There is no need to complete the application complete stop , as this can lead to the loss of information about the binding if you configured your bindings without re-exporting.
As the error message says, you need to complete all instances of the service and / or messaging related to the application.
Go to the BizTalk Group page in the BizTalk Administrator, click on the "Suspended Instances" link, then right-click and select "Teminate Instances" from the pop-up menu.
You can now redistribute your BizTalk project. Be sure to restart any associated host instances, or you will not see your changes at runtime.
source share