It is definitely possible. Do not look at the api widget for this. Take a look at the api filter. WordPress has an api that allows you to filter content before it is sent to the browser. In this case, you would do something like this:
function my_super_awesome_content_filterer( $content ){ $content = preg_replace( '#([AZ]+)#', '<a href="wictionary.definition.address=$1">$1</a>', $content ); } add_filter( 'the_content', 'my_super_awesome_content_filterer' );
Read more about filters here:
http://codex.wordpress.org/Plugin_API#Filters
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