I recommend that you do not force the user to use it. Try directly applying user input. This simplifies your application because the user does not need to worry about it. In any case, you must give the user feedback on your changes. Show him the message "your entry has been saved" (without a message box). Try to avoid all the steps that are not needed. This makes your application or web page more user friendly.
In addition, no user wants to memorize "hot keys" for thousands of programs.
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