Yes. This year 's DrupalCamp Colorado site , for example, is HTML5 and (of course) Drupal. All current versions of Drupal (5, 6, and 7) have flexible markup systems, so they are irrelevant. And how? "This is a really general question without indicating your knowledge of the topic in Drupal and / or your understanding of HTML5. But basically you take HTML5 markup and you put it in your theme. What is it.
It seems like all the hype surrounding HTML5 convinced you of something significantly more complex than HTML4 or XHTML. This is not true.
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