If you mean simple Zope2 from zope, then I will go to Django. The most interesting things in the Zope world happen with Plone or Grok (which is Zope3, which is actually very different from Zope2).
Grok works great with relational databases, Plone doesn't actually work, so if you are dependent on a DBMS, either go with Grok or Django.
Zope and Plone have a pretty steep learning curve, so you'll get started with Django faster.
The biggest drawback of Django is, in my opinion, that it tries to do everything by itself (templating, publishing objects, ORM, etc.), while there are many great existing components. If you want to use your code / knowledge outside the web structure you use, consider Pylons or BFG
Many options, no clear answer, sorry :)
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