One word: yes :)
Use Firebug or the IE developer tools, as usual, make sure the current page has script links to the jQuery library, then go to the city on your selectors!
This is a good way to test the selector and functionality before including it in your code.
EDIT: read the question a bit wrong, but the answer is still the same. Whether it's an address bar or a console window, you can use jQuery. Try putting javascript:$("#content").remove() in your address bar while viewing this page and see what happens;)
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