You can use boolean indexing and state with isin , turning the boolean Series is ~ :
import pandas as pd USERS = pd.DataFrame({'email':[' a@g.com ',' b@g.com ',' b@g.com ',' c@g.com ',' d@g.com ']}) print (USERS) email 0 a@g.com 1 b@g.com 2 b@g.com 3 c@g.com 4 d@g.com EXCLUDE = pd.DataFrame({'email':[' a@g.com ',' d@g.com ']}) print (EXCLUDE) email 0 a@g.com 1 d@g.com
print (USERS.email.isin(EXCLUDE.email)) 0 True 1 False 2 False 3 False 4 True Name: email, dtype: bool print (~USERS.email.isin(EXCLUDE.email)) 0 False 1 True 2 True 3 True 4 False Name: email, dtype: bool print (USERS[~USERS.email.isin(EXCLUDE.email)]) email 1 b@g.com 2 b@g.com 3 c@g.com
Another solution with merge :
df = pd.merge(USERS, EXCLUDE, how='outer', indicator=True) print (df) email _merge 0 a@g.com both 1 b@g.com left_only 2 b@g.com left_only 3 c@g.com left_only 4 d@g.com both print (df.loc[df._merge == 'left_only', ['email']]) email 1 b@g.com 2 b@g.com 3 c@g.com
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