Justin Beckwith's answer was correct for a managed virtual machine (VM: true) using a compatibility runtime, but it was completely deprecated. (His answer was 100% correct when he wrote the answer.)
The new flexible application engine (env: flex) cannot use any of the standard library of application engines, so all of the above functions require minimal changes in your code and significant changes in some cases.
For example, the cloud storage API has been changed and you will need to update your code to reflect this. But if you used Objectify to access the data warehouse, then you really are going to write significant pieces of code. In addition, memcache is not currently supported.
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