The comma operator is an operator that can be used inside an expression. It is used to highlight several different expressions and has the meaning of "evaluate all of the following expressions and then produce the value of the final expression." For example:
a = 1, b = 2, c = 3
means "evaluate a = 1 , then b = 2 , then c = 3 , then evaluate the value of the expression c = 3 .
The semicolon is not an operator and cannot be used inside an expression. It is used as part of JavaScript syntax to indicate the end of an expression that is considered an operator. For example, you could say
a = 1; b = 2; c = 3;
And this will mean "there are three operators in the sequence: evaluate the first expression as the first operator, the second expression as the second statement, and the third expression as the third operator."
In this regard, the two are not completely interchangeable. For example, you cannot write
var a = 1, var b = 2;
Because var a = 1 and var b = 2 are operators, not expressions, and therefore cannot be separated by commas. Here you must use a semicolon.
(Note: you could say
var a = 1, b = 2;
because the language specifically allows this comma to be used as part of the syntax of the declaration statement. Here the comma is not used as an operator.)
Similarly, you cannot say
a = (b = 1; c = 2);
Because here the right side of the expression should be an expression, not an expression, but ; used to separate operators. Instead, the internal semicolon should be a semicolon. (Again, this code is rather inconvenient and unusual in the first place, so you probably shouldn't do that!)
From a stylistic point of view, the comma operator is rarely used and not hidden enough for it to deploy JavaScript codecs that are competent enough. As a result, I would strongly recommend not using it and instead following the established conventions in JavaScript about using semicolons to complete statements, even if it would be equivalent and syntactically legal to use commas to highlight expressions that each of them is used as statements.
Hope this helps!